no increase in post-vaccination complications

Pregnant women, if they have Covid-19, are more at risk than others of developing a severe form of the disease. For example, according to the Ministry of Health, they would be four times more likely to be admitted to intensive care than women of the same age who are not pregnant, a risk that increases as pregnancy progresses. It is normal during pregnancy to be able to ask questions about the benefits of the vaccine for you and your future baby. In its opinion of November 17, 2021, the National College of French Obstetricians and Gynecologists recommends vaccination for all pregnant women, regardless of the stage of pregnancy. In addition, the Vaccine Strategy Guidance Council, in its communication of February 2, 2022, recalls the importance of vaccination, including as a booster shot, for them.

There are therefore many reassuring studies on the subject, as explained by Inserm in its Canal Detox review, as well as the Reference Center for Teratogenic Agents (CRAT). The latest study, published in the journal JAMA and conducted by researchers from the Karolinska Institute, shows that vaccination against COVID-19 is not associated with a higher risk of pregnancy complications. The study, which included nearly 160,000 pregnancies, found no increased risk of preterm birth, stunted growth or greater need for newborn care in children whose mothers were vaccinated. ” Reassuring results that hopefully can make pregnant women more willing to vaccinate. », estimates the co-first author of the study, Professor Anne Örtqvist Rosin.

If the mother is vaccinated, the child is protected

The researchers chose to conduct this study because they found that vaccination rates among pregnant women are often lower than those of the rest of the population. In France, ANSM* data show that on January 6, 2022, 29.8% of pregnant women had not received a dose of vaccine against Covid-19 and that on the same day the rate of pregnant women who had not received 2 doses was reached 39 .4%. A delay often stemming from concerns that pregnant women were not included in large clinical trials when the vaccines were being made. The researchers did this by linking the Swedish pregnancy registry and the Norwegian medical birth registry to each country’s vaccination registry to obtain data on if and when pregnant women were vaccinated with which vaccine.

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The study included 157,521 women who gave birth between January 2021 and January 2022, 18% of whom were vaccinated. The scientific team found that vaccinated women were no more at risk of developing any of the complications studied than unvaccinated women. The majority of pregnant women included in the study were vaccinated after week 12 according to the recommendations in those countries, with 95% known to have received an mRNA vaccine (Pfizer-BioNTech or Moderna). Their results also confirmed what other scientific work has already shown: Another potential benefit of vaccination during pregnancy is that the antibodies produced cross the placenta and offer the newborn some protection against COVID-19.

Note that the Ministry of Health in its “Frequently Asked Questions” about vaccination during pregnancy states that the active ingredient in the vaccine is excreted from the mother’s body a few days after the injection. It therefore does not circulate in the maternal blood or in the placenta, unlike the antibodies that are transmitted from the mother to the fetus: only the immune response persists. ” We now want to investigate how long this protection lasts and whether a SARS-CoV-2 infection or vaccination during pregnancy has any other lasting effects on the health of the child. ‘ the researchers conclude. For those wondering about this topic, the Ministry has published on its YouTube channel a series of short interviews with Pr Alain Fischer, pediatrician and President of the Vaccine Strategy Orientation Council.

*The National Agency for the Safety of Medicines and Healthcare Products

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