The hormone beta-HCG (chorionic gonadotropin hormone) is produced in early pregnancy when the egg begins to nest. what is his role How is its development during pregnancy? Per week ? How do you interpret a low or high rate? Table of standards, dosing method, calculation…
L’Beta HCG hormone is commonly referred to as the “pregnancy hormone”. It is produced at the very beginning of pregnancy after conception. Which is its development during pregnancy? Per week ? Why is it important to monitor his rate during pregnancy ? How is an HGC hormone test performed? How are the results of the analysis to be interpreted? Reply.
Definition: What is Beta HCG Hormone?
“L’Hormone chorionic gonadotrope (also called Beta HCG hormonehuman chorionic gonadotropin) is a hormone secreted by the chorion (the outer membrane of the embryo that ensures contact with the lining of the uterus: this will become the placenta) at the beginning of pregnancy. This hormone begins to be produced when it is present implantation of the egg in the lining of the uterus“, explains Dr. Thierry Harvey, gynecologist and director of Deaconess Maternity, in Paris. The beta-HCG hormone is therefore only present in sufficient concentration during pregnancy secreted only in pregnant women, from the beginning of the development of the embryo around the 10th day of pregnancy. This hormone is primarily used to maintain the corpus luteum, an endocrine gland in the ovary responsible for secreting progesterone and estrogen during the first trimester of pregnancy. It is detectable in urine and blood throughout pregnancy, but extremely variable rates. Finally, on very rare occasions,”This hormone can be secreted in people (male or female) who have ovarian diseases, such as certain types of ovarian or testicular tumors. This is the only case when a pregnancy test in a man is positive.‘ adds the expert.
It reaches its peak between the 7th and 12th week of pregnancy.
What is Plasma Beta HCG Hormone?
Blood levels of this hormone (commonly known as plasma beta-hCG or serum beta-hCG) rise steadily and gradually during the first 8 weeks of pregnancy doubles every 48 hours. It reaches its peak between the 7th and 12th week of pregnancy. Generally around the 4th month of pregnancy, the rate gradually decreases until the end of pregnancy. After childbirth, the beta-HCG hormone in the woman’s body gradually decreases until it disappears completely. The prices below are indicative. Best to send the results to the prescribing doctor, your midwife, your gynecologist or the doctor of the analysis laboratory.
What is Beta HCG Hormone Calculation?
The beta-HCG hormone doubles approximately every 48 hours in early pregnancy. To calculate the HCG hormone level in the blood, you need to know the result of the first HCG level analysis. Based on this rate, the following calculator estimates whether or not you are pregnant and for how long. (Level obtentionido de hCG: beta-HCG level)
Table: How does beta-HCG develop during pregnancy (per week)?
|day/week of pregnancy||Average Beta HCG Level (in mIU/L)|
|0||Less than 5|
|7 days||Between 5 and 20|
|2 weeks||Between 100 and 6,000|
|3 week||Between 1,500 and 25,000|
|4th week||Between 2,400 and 70,000|
|5th week||Between 10,000 and 130,000|
|6th week||Between 30,000 and 190,000|
|7th week||Between 35,000 and 160,000|
|8th week||Between 25,000 and 140,000|
|2-3 months||Between 30,000 and 100,000|
|Between 10,000 and 30,000|
|Beyond the 25th week
|Between 5,000 and 15,000|
|No pregnancy||< 15 mUI/mL|
When and Why Should a Beta HCG Hormone Test Be Prescribed?
If in theory for a normal pregnancy the Plasma beta HCG hormone assay is not usefulmost maternities recommend having a Plasma dosage of the so-called qualitative beta-HCG hormone Either to confirm the pregnancy or to make sure it’s going well. Namely that this dosage is much more accurate and reliable than a urine pregnancy test (a positive pregnancy test does not systematically confirm the certainty of pregnancy, on the other hand, if the woman is pregnant, the HCG level exceeds the 5 IU/L in the blood when nesting). Only the dosing of HCG makes it possible to confirm or reverse pregnancy and accurately date the onset of pregnancy. “If, on the other hand, the pregnant woman bleeds during pregnancy, we will then prescribe an ultrasound and a dosage of the hormone beta-HCG, which allows you to learn a little more about her pregnancy: Is there a risk of miscarriage? Is this an ectopic pregnancy? Is it a multiple pregnancy (twins, triplets…)?… In this case, the The dosage will be quantitativethat is, this test yields a number that must be interpreted since beta-HCG hormone levels are known to double every 48 hours in a normal pregnancy“, explains the gynecologist. It is also possible to prescribe a dosage of the hormone beta-HCG to detect possible chromosomal abnormalities (in the case of screening for trisomy 21, in this case the level of HCG will be higher than normally expected). This Results must be combined with other markers or placental tumors, which are very rare.
If it is performed under a doctor’s prescription, it is fully subject to social insurance. Don’t forget to bring your doctor’s prescription and your vital and health insurance cards with you.
- The examination is first arranged by a doctor duringa consultation in a practice or in the hospital. Beta HCG hormone dosage takes place in a medical analysis laboratory.
- After installing and applying a tourniquet, the doctor will measure the plasma level of the beta-HCG hormone, which is made up of it into a collection of one or more tubes of blood (they usually contain 5 ml of blood each).
- After the sample is taken, pressure is applied to the puncture site for a few minutes.
- This tube will then be analyzed and the results will be sent to you. between 24 and 48 hours after collection through a mail. Regardless of the results (regardless of whether they appear abnormal or not), it is advisable to send them to the prescribing doctor who, depending on the results, can decide whether or not additional tests are carried out.
- At the end of this investigation there are no special indications: you can eat and live normally.
Do you have to be fasting for the Beta HCG hormone test?
It is not no need to fast to do a beta hCG hormone test.
What is the normal level of the HCG hormone?
|Normal HCG level|
|children and men||less than 1 IU/L|
|ovulating women||less than 2 IU/L|
|postmenopausal women||less than 7 IU/L|
|Pregnant women (10th day after fertilization)||Above 5 IU/L, but usually between 8 and 10 IU/L|
Negative Beta HGC: what does it mean?
It is assumed that the beta hCG assay is negative if the obtained value is less than 5 IU/L. This means that the woman is not pregnant.
Positive Beta HGC: what does it mean?
It is assumed that the beta hCG assay is positive when is the value obtained greater than 5 IU/L. This means that the woman is pregnant.
Low Beta HCG Levels: What Does It Mean?
During a miscarriage, the level of the hormone beta-HCG increases breakdowns (Remember that in a normal pregnancy, levels of the beta-HCG hormone should double every 48 hours and then level off by the end of the third month of pregnancy). In addition, “In an ectopic pregnancy (the egg attaches in one place but does not attach to the uterus), beta-HCG levels are significantly lower than normal levels for that week of pregnancy. Depending on the HCG value, we prescribe a drug treatment (equivalent to chemotherapy) and, above all, monitor the decrease in these hormones“, assures the gynecologist.
High Beta HCG Levels: What Does It Mean?
► A molar pregnancy. An exponentially increasing beta HCG level (100,000 IU/L, 200,000 IU/L and above) can be a sign of one molar pregnancy (that’s very rare). The birthmark is a benign tumor with malignant potential, which is an overdevelopment of placental cells: no embryo is visible because the uterus is filled with these small cells. Namely that an ultrasound is always mandatory to confirm molar pregnancy or not. After removal of the mole, it is necessary to monitor that the HCG level reaches 0 and does not rise again, which could be a sign of a recurrence of the mole or choriocarcinoma (cancer of the placenta that occurs during a pathological pregnancy).
► A multiple pregnancy (twins…). In a multiple pregnancy, the beta-HCG level is significantly higher than in a singleton pregnancy. However, a high rate does not necessarily confirm that the pregnancy is multiple. Only an ultrasound can reliably confirm a multiple pregnancy. Last but not least, “If the multiple pregnancy is confirmed, these women are immediately offered non-invasive screening for trisomy 21‘ concludes Dr. Harvey.
thanks to dr Thierry Harvey, gynecologist and head of the Deaconess Maternity in Paris.